How to Read a Study Listed on the Clinical Trials.gov Website
Pediatric Stroke Research Studies and Clinical Trials – Located in United States
The following studies are listed in alphabetical order, by state. More details and contact information can be located by clicking on the title of each study.
Transcranial Magnetic Stimulation in Children With Stroke (TMSCS)
This is a pilot study of repetitive transcranial magnetic stimulation (rTMS) to test tolerance and efficacy in children who have hemiparesis from acquired or presumed perinatal stroke. 6 years to 18 years. Ohio.
Asymmetrical Gait Training After Pediatric Stroke
The purposes of this pilot research study are 1. To begin to test if two different types of physical therapy might have different results in children and adolescents who have had a prior stroke, and 2. To determine if either type of physical therapy causes changes in the brain signals that control leg muscles. Ages 5 years to 17 years. Pennsylvania.
Optical Measurement of Cerebral Hemodynamics in Children With Acute Arterial Ischemic Stroke
Acute ischemic stroke affects roughly 1 in 50,000 children every year and is one of the top ten causes of death in children. Currently, caregivers lay the affected child flat in hopes of increasing blood flow to the brain and reducing the volume of the brain which is damaged. However, there are currently no techniques to measure brain blood flow at the child’s bedside and indicate if this treatment is effective. We will probe brain blood volume, oxygen saturation, and flow with red light to determine the efficacy of this intervention. Ages 2 years to 18 years. Pennsylvania.
Umbilical Cord Blood in the Treatment of Stroke in Children. (Pedi Stroke)
This study will enroll ten pediatric patients who have their umbilical cord blood banked with Cord Blood Registry, Inc. (CBR), who have been diagnosed with an arterial ischemic stroke (AIS), and whose caregivers contacted CBR, Inc. to notify them that the child has experienced an AIS around the time of birth. The specific aims of this study are: 1.To determine if Human Umbilical Cord Blood (hUCB) infusion is safe in children with perinatal arterial ischemic stroke (AIS). 2.To determine if late functional outcome, physiologic response, and anatomic findings are changed following hUCB infusion in children with perinatal AIS. Ages 6 weeks to 6 years. Houston, Texas.
Pediatric Stroke Research Studies and Clinical Trials – Multiple Locations in United States and Canada
Thrombolysis in Pediatric Stroke (TIPS)
Thrombolysis in Pediatric Stroke (TIPS) is a five-year multi-center international safety and dose-finding study of intravenous (IV) tPA in children with acute ischemic stroke (AIS) to determine the maximal safe dose of intravenous Tissue Plasminogen Activator (IV-tPA) among three doses (0.75. 0.9, 1.0 mg/kg) for children age 2-17 years within 4.5 hours from onset of acute AIS. California, Colorado, Massachusetts, Ohio, Tennessee, Texas, Utah, Washington, and Alberta Canada.
The Vascular Effects of Infection in Pediatric Stroke (VIPS) Study
The Vascular effects of Infection in Pediatric Stroke (VIPS) study is a multicenter cohort study that will test the hypotheses that (1) infection can lead to childhood AIS by causing vascular injury, and (2) the resultant arteriopathy, and inflammatory markers, predict recurrent stroke. Ages 1 month through 18 years. Multiple locations.
Canadian Pediatric Stroke Research and Clinical Trials
Intensive Motor Training After Perinatal Stroke to Enhance Walking
Early childhood injuries such as perinatal (around birth) stroke are devastating because the child lives with the problem for life, typically close to a typical lifespan. One ‘opportunity’ presented by a brain injury early in life compared to later in adulthood is that the young brain is much more plastic (malleable) and receptive to interventions. This is particularly true for neural circuits that are still under development. This study will test the hypothesis that early (<2 yr old), intensive leg training will improve walking more than no training or training at >2 yr old. They will further determine the changes induced by training in motor and sensory pathways. Ages 8 months to 3 years. Alberta, Canada.
Modulation of Brain Plasticity After Perinatal Stroke (PLASTIC CHAMPS)
A study of the ability of two interventions to modulate brain plasticity toward better function in children with stroke-induced CP. One intervention is a rehabilitation method called constraint-induced movement therapy (CIMT), the other is a type of non-invasive brain stimulation called transcranial magnetic stimulation (TMS). Ages 7-18. Alberta, Canada.
CHASA’s Role
As part of CHASA’s mission to increase scientific and medical knowledge regarding childhood hemiparesis, hemiplegia, hemiplegic cerebral palsy, pediatric stroke, infant stroke, and other causes of hemiplegia in children, we continues to assist investigators in gathering information that may contribute to knowledge in these fields. CHASA does not endorse these studies, but simply provides this information as a courtesy to families and researchers.
